Bio

marco

I am currently a researcher at the University of Surrey investigating the role of lipid enriched tumour-associated macrophages in ovarian cancer under the supervision of Dr Fernando Martinez Estrada. Prior to this position, I investigated the human innate immune response to commensal microbiota under the supervision of Dr Jorge Gutierrez-Merino. From 2017-2020, I was a postdoctoral researcher at UCL Great Ormond Street Institute of Child Health utilising translational readthrough therapy and omics approaches for paediatric primary mitochondrial disease research in Prof Shamima Rahman’s group.

My introduction to research started while studying nutrition at the University of Surrey where I obtained a BSc with a placement year at Stockholm University studying obesity and brown adipose tissue metabolism in Prof Jan Nedergaard's group. In 2016, I completed a PhD in Nutritional Sciences and Systems Biology at Surrey, and a three month placement at British Nutrition Foundation, under the supervision of Dr J. Bernadette Moore, Prof Nick Plant, Prof Andrzej Kierzek, and Dr Marcus Tindall. For my PhD, I studied non-alcoholic fatty liver disease utilising in vitro models, quasi-steady state petri net modelling with a human hepatic genome scale metabolic network, and introduced dynamic flux variability analysis (dFVA) for constraint-based modelling.

Before joining UCL, I undertook two research projects partnered with industries with Prof John McVey at Surrey to characterise a recombinant human factor VIII (rhFVIII) variant from conditioned media, and to produce rhFVIII variants using a lentiviral platform.



Publications

Highly recruited brown adipose tissue does not in itself protect against obesity
von Essen G, Lindsund E, Maldonado EM , Zouhar P, Cannon B, and Nedergaard J
Molecular Metabolism 2023
Website
Bi-allelic Variants in TKFC Encoding Triokinase/FMN Cyclase Are Associated with Cataracts and Multisystem Disease
Wortmann SB*, Meunier B*, Mestek-Boukhibar L, van den Broek F, Maldonado EM , Clement E, Weghuber D, Spenger J, Jaros Z, Taha F, Yue WW, Heales SJ, Davison JE, Mayr JA, and Rahman S
American Journal of Human Genetics 2020
Website
Systems biology approaches toward understanding primary mitochondrial diseases
Maldonado EM, Taha F, Rahman J, and Rahman S
Frontiers in Genetics 2019
Website
Multi-scale, whole-system models of liver metabolic adaptation to fat and sugar in non-alcoholic fatty liver disease
Maldonado EM, Fisher CP, Mazzatti DJ, Barber A, Tindall MJ, Plant NJ, Kierzek AM, and Moore JB
npj Systems Biology and Applications 2018
Website
Proteomic identification and characterization of hepatic glyoxalase 1 dysregulation in non-alcoholic fatty liver disease
Spanos C, Maldonado EM, Fisher CP, Leenutaphong P, Oviedo-Orta E, Windridge D, Salguero FJ, Bermúdez-Fajardo A, Weeks ME, Evans C, Corfe BM, Rabbani N, Thornalley PJ, Miller MH, Wang H, Dillon JF, Quaglia A, Dhawan A, Fitzpatrick E and Moore JB
Proteome Science 2018
Website
Integration of Genome Scale Metabolic Networks and Gene Regulation of Metabolic Enzymes with Physiologically Based Pharmacokinetics
Maldonado EM, Leoncikas V, Fisher CP, Moore JB, Plant NJ, and Kierzek AM
CPT: Pharmacometrics and Systems Pharmacology 2017
Website
An investigation of the role of glucose and fructose in non-alcoholic fatty liver disease using systems approaches
Maldonado, EM
PhD Thesis, University of Surrey 2017
Website

Abstracts

Intracellular sensing of beneficial bacteria: an alternative probiotic therapy approach?
Maldonado EM (presented), Maluquer de Motes C, Gutierrez-Merino J
13th International Symposium on Lactic Acid Bacteria; Online (poster) 2021
Poster
Making sense of nonsense mutations in pediatric primary mitochondrial disease in vitro
Rahman J, Maldonado EM (presented), Kuo M, Rahman S
Mitochondria in Human Disease; Stockholm, SE (poster) 2019
Development of a dynamic multi-scale, computational model of human hepatic glucose and fructose metabolism
Maldonado EM, Tindall MJ, Plant NJ, Kierzek, AM and Moore, JB
Proceedings of the Nutrition Society; Dublin, IE (oral) 2016
Website
Quantitative lipid profiling of the early response to either fructose or glucose in an in vitro model of steatosis
Maldonado EM, Fielding BA, Fisher CP and Moore JB
Proceedings of the Nutrition Society; Nottingham, UK (oral) 2015
Website
Examination of methylglyoxal levels in an in vitro model of steatosis and serum from patients with non-alcoholic fatty liver disease
Maldonado EM, Rabbani N, Thornalley PJ, Wang H, Miller M, Dillon JF, and Moore, JB
Proceedings of the Nutrition; Glasgow, UK (oral) 2014
Website
cvmp logo Systematic characterisation of in vitro hepatocyte models for studying non-alcoholic fatty liver disease
Maldonado EM, Passmore R, Fisher CP, and Moore JB
British Association for the Study of the Liver; London, UK (poster) 2013
Poster

CV

Experience

Postdoctoral Researcher
University of Surrey, Guildford, UK
March 2023 - Present
Independent Researcher
University of Surrey, Guildford, UK
December 2021 - March 2023
Postdoctoral Researcher
University of Surrey, Guildford, UK
November 2020 - December 2021
Visiting Researcher
University College London, Institute of Child Health, London, UK
July 2020 - January 2022
Research Associate (Honorary Contract)
Great Ormond Street Hospital, London, UK
April 2018 - January 2022
Postdoctoral Research Associate
University College London, Institute of Child Health, London, UK
October 2017 - July 2020
Postdoctoral Researcher
University of Surrey, Guildford, UK
December 2016 - September 2017
Nutrition Scientist Intern
British Nutrition Foundation (BNF), London, UK
October 2014 - January 2015
Research Assistant
Department of Nutritional Sciences, University of Surrey, Guildford, UK
January 2013 - April 2013
Extramural Research Student (ERASMUS)
Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden
August 2009 – July 2010

Education

Google Project Management: Professional Certificate
Coursera
April 2025 - Present
PhD Nutritional Sciences and Systems Biology
University of Surrey, Guildford, UK
October 2012 - September 2016
BSc (Hons) Nutrition
University of Surrey, Guildford, UK
September 2007 - June 2011
Natural Science Programme
Internationella Engelska Gymnasiet, Stockholm, Sweden
September 2004 - June 2007

For a detailed CV, please contact me.